Background. The aim of this study was to investigate maspin and ezrin expression in different subtypes of periocular basal cell\ncarcinoma (BCC). Methods. Tissue samples from 43 patients with periocular BCC. Our cases were comprised of 10 morpheaform,\n25 nodular, and 8 adenoid type BCCs. Immunohisto chemical staining for maspin and ezrin was performed by Envision detection\nsystem. Results. There was no difference between different subtypes of BCC in maspin expression regarding positivity, intensity, and\npattern of expression. Ezrin was expressed in all subtypes of BCC but the intensity was significantly higher in morpheaform BCC\ncompared to nodular and adenoid types (???? < 0.001 and ???? = 0.012, resp.); ninety percent of morpheaform samples showed strong\nezrin intensity, while this strong intensity was only present in 25% and 12% of adenoid and nodular subtypes, respectively.There was\nno correlation between age, sex, or tumor margin involvement and expression of neithermaspin nor ezrin.There was no correlation\nbetween maspin and ezrin expression except in nodular type, in which an inverse correlation was found (???? = 0.004). Conclusion.\nEzrin is expressed intensely in morphea form BCC of periocular region. Further studies are needed to show the significance of this\nfinding in prognosis of morphea form BCC.
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